Estradiol 17-beta-dehydrogenase 1(HSD17B1) is a member of the short-chain dehydrogenases/reductases(SDR) family. The HSD17B1 protein advances the reduction of estrogens and androgens. In addition, the HSD17B1 has a 20-alpha-HSD activity. HSD17B1 preferentially uses NADH.