Phosphoglycolate phosphatase(PGP) is discovered in all tissues including red cells, lymphocytes and cultured fibroblasts(at protein level). PGP is most active in skeletal muscle and cardiac muscle. The catalytic activity of PGP is 2-phosphoglycolate + H2O = glycolate + phosphate. Diseases associated with PGP include tardive dyskinesia and polycystic kidney disease.