POLR2J2 belongs to the RNA polymerase II subunit 11 gene family， that includes 3 genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. DNA directed RNA polymerase II polypeptide J family encodes a subunit of RNA polymerase II， the polymerase which is responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple， otherwise spliced transcripts which express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3’ end that makes them candidates for nonsense-mediated decay（NMD). Therefore， it is unknown if this locus expresses a protein or proteins in vivo.
