Proteasome Subunit Beta Type 8（PSMB8) is a member of the peptidase T1B family. The proteasome is a multicatalytic proteinase complex with well-organized ring-shaped 20S core structure. Proteasomes are spread through eukaryotic cells at a high concentration. PSMB8 is mainly expressed in immature dendritic cells. vital function of a modified proteasome， the immunoproteasome， is the processing of class I MHC peptides.PSMB8 is positioned in the class II region of the MHC（main histocompatibility complex). PSMB8 plays as a significant factor of interferon gamma-induced sensitivity and in apoptosis by degradation of the apoptotic inhibitor MCL1.
