Activation-Induced Cytidine Deaminase（AICDA) belongs to the the cytidine deaminase family. AICDA is involved in somatic hypermutation， gene conversion， and class-switch recombination in B-lymphocytes. AICDA is necessary for a number of crucial steps of B-cell terminal differentiation needed for efficient antibody responses. AICDA has a role in the epigenetic regulation of gene expression by participating in DNA demethylation. AICDA is strongly expressed in the lymph nodes and tonsils.
