Prostaglandin Reductase 2（PTGR2) is a member of the medium-chain dehydrogenase/reductase superfamily. PTGR2 is an enzyme involved in the metabolism of prostaglandins. PTGR2 catalyzes an NADPH-dependent reduction of the conjugated alpha， beta-unsaturated double bond of 15-keto-PGE（2)， which is a fundamental step in terminal inactivation of prostaglandins and suppression of PPARgamma-mediated adipocyte differentiation. Selective inhibition of PTGR2 may be a factor in the improvement of insulin sensitivity with fewer side effects. PTGR2 may also be involved in controlling activation of the peroxisome proliferator-activated receptor.
