SULT2B1 catalyzes the sulfate conjugation of numerous hormones， neurotransmitters， drugs and xenobiotic compounds. Sulfonation enhances the water solubility of molecules， and therefore their renal excretion， however it can also result in bioactivation to form active metabolites. SULT2B1b is localized in the cytosol and nuclei of human cells. SULT2B1b is selective for the sulfation of 3beta-hydroxysteroids such as dehydroepiandrosterone and pregnenolone， and participates in cholesterol sulfation in human skin.
