PARP1 takes part in the base excision repair pathway， by catalyzing the poly ADP-ribosyl of a restricted number of acceptor proteins involved in chromatin architecture and in DNA metabolism.. PARP1 mediates the poly ADP-ribosy of APLF and CHFR. PARP1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. PARP1 is a chromatin-associated enzyme， poly（ADP-ribosyl) transferase， which modifies various nuclear proteins by poly ADP-ribosyl. PARP1 takes part in the regulation of various significant cellular processes such as differentiation， proliferation， and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. PARP1 is a site of mutation in Fanconi anemia， and is involved in the pathophysiology of type I diabetes.
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的人聚ADP核糖聚合酶1（PARP1）产品为过滤灭菌的无色溶液；其中人聚ADP核糖聚合酶1（PARP1）产品溶解于20mM Tris pH 8， 1Mm DTT，10%甘油溶液中.
