NFNB demonstrates the capability to reduce quinines. NFNB enzyme activates prodrugs in antibody directed enzyme prodrug therapy. NFNB reduces nitrofurazone, quinones and anti-tumor agent CB1954(5-(aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species.
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的大肠杆菌二氢蝶呤还原酶(NFNB)产品为过滤灭菌的无色溶液;其中1mg/ml大肠杆菌二氢蝶呤还原酶(NFNB)产品溶解于20mM Tris pH 8, 1mM DTT, 0.05M NaCl,10%甘油溶液中.