NNMT is part of the family of transferases， especially those transferring one-carbon group methyltransferases. NNMT is mostly expressed in the liver， and a lower expression is seen in the kidney， lung， skeletal muscle， placenta and heart. NNMT catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is significant for biotransformation of many drugs and xenobiotic compounds. NNMT is accountable for the enzymatic activity which uses S-adenosyl methionine as the methyl donor. NNMT expression is related with tumor stage and DFS time in hepatocellular carcinoma cases. NNMT is a good candidate as a tumor marker of various kinds of cancers. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer.
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的人尼克酰胺N-甲基转移酶（NNMT）产品为过滤灭菌的无色溶液；其中人尼克酰胺N-甲基转移酶（NNMT）产品溶解于20mM Tris pH 8.0，20%甘油溶液中.
