AKR1B10 efficiently reduces aliphatic and aromatic aldehydes， and it is less active on hexoses. AKR1B10 is highly expressed in adrenal gland， small intestine， and colon， and may play an important role in liver carcinogenesis. AKR1B10 is a monomeric protein that competently catalyzes the reduction of aromatic and aliphatic aldehydes and ketones. AKR1B10 is widely expressed in numerous human tissues， small intestine， colon and adrenal gland. AKR1B10 is pathogenically involved in diabetic complications and is overexpressed in human tumors， such as liver， breast， and lung cancer， AKR1B10 is involved in the development and progression of cancer.
