PPIL1 belongs to the cyclophilin family of peptidylprolyl isomerases（PPIases).
The cyclophilins are a well conserved， ubiquitous family， members of which take an significant part in protein folding， immunosuppression by cyclosporin A， and infection of HIV-1 virions. PPIL1 protein increases the folding of proteins and catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIL1 is involved in proliferation of cancer cells through modulation of phosphorylation of stathmin. PPIL1 is a novel molecular target for colon-cancer therapy.
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大肠杆菌中重组表达
溶解建议
提供的人肽酰脯氨酰异构酶（亲环蛋白)样1（PPIL1）产品为过滤灭菌的无色溶液；其中人肽酰脯氨酰异构酶（亲环蛋白)样1（PPIL1）产品溶解于20 mM Tris-HCl缓冲液（pH 8.0)，20%甘油溶液中.
