Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer’s disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein(APP) by two proteases, one of which is the protein encoded by this gene. BACE1 is a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene.
BACE1 is responsible for the proteolytic processing of the amyloid precursor protein(APP). BACE-1 cleaves at the n-terminus of the a-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated c-terminal fragment which is later released by gamma-secretase.
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该【BACE1】重组人B位淀粉样前体蛋白裂解酶1Recombinant Human Galactose-1-Phosphate Uridylyltransferase是Prospec品牌中国区域代理商艾美捷科技产品,具体的蛋白序列可查看提供的英文版本产品说明书。