Human Ubquitin-conjugating enzyme 7（UbcH7) is a ubiquitin-conjugating enzyme（E2) mediating c-fos degradation， transcription factor NF-B maturation， and human papilloma virus-mediated p53 and Myc protein degradation， in vitro. The ubiquitin-conjugating enzymes（E2s) are essential components of the post-translational protein ubiquitination pathway， mediating the transfer of activated ubiquitin to substrate proteins. The human UBE2L1-UBE2L4 gene could potentially encode different isoforms of the UbcH7. UBE2L3 gene， located at chromosome 22q11.2， is the only identical family member with introns and encodes a polypeptide sequence identical to that of UbcH7.
