MAT2A is an important enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine(SAMe) from L-methionine and ATP. MAT2A is expressed in extrahepatic tissues. In liver, MAT2A expression associates with growth, dedifferentiation, and cancer. NF-kappa B and AP-1 are necessary for basal MAT2A expression in HepG2 cells and mediate the increase in MAT2A expression in response to TNF-alpha. Up-regulation of MAT2A provides growth improvement and s-adenosylmethionine and methylthioadenosine thus can block mitogenic signaling in colon cancer cells. Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells.
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的蛋氨酸腺苷转移酶II,Alpha(MAT2A)产品为过滤灭菌的无色溶液;其中1mg/ml蛋氨酸腺苷转移酶II,Alpha(MAT2A)产品溶解于20mM Tris pH 8,10%甘油溶液中.