Full-length recombinant human neutrophil pro-collagenase（MMP-8)， latent form.
Matrix metalloproteinase 8（MMP-8)， or neutrophil collagenase， degrades interstitial collagens， acting preferentially on collagen type I.
Increased full-length MMP-8 protein was associated with infiltration into the skin of neutrophils， which are the major cell type that expresses MMP-8.
MMP-8 is synthesized and stored in specific granules in neutrophil leukocytes. MMP-8 activity is therefore regulated by factors such as surface-bound ligands（IgG or complement components) that release it through degranulation.Once released and activated through proteolytic or oxidative mechanisms， MMP-8 plays a major role in the connective tissue turnover that accompanies inflammatory processes.
