TSTA3 is a NADP（H)-binding protein. TSTA3 catalyzes the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism， converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of numerous fucosyltransferases that take part in the expression of several glycoconjugates， including blood group ABH antigens and developmental adhesion antigens.
Mutations in TSTA3 result in leukocyte adhesion deficiency， type II.
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的人组织特异移植抗原P35B（TSTA3）产品为过滤灭菌的无色溶液；其中0.5mg/ml人组织特异移植抗原P35B（TSTA3）产品溶解于20mM Tris pH 8， 2mM DTT， 0.05M NaCl，10%甘油溶液中.
