OGG1 is a DNA glycosylase enzyme which takes part in base excision repair. OGG1 protein is the main enzyme accountable for the excision of 7,8-dihydro-8-oxoguanine(8-oxoG), a mutagenic base byproduct which arises as a result of exposure to reactive oxygen species(ROS). OGG1 shows beta lyase activity that nicks DNA 3’’ to the lesion.