PSMB6 belongs to the proteasome B-type family（T1B family) which is a 20S core beta subunit in the proteasome. The PSMB6 is not present in the immunoproteasome and is replaced by PSMB9. The proteasome is a multicatalytic proteinase complex with an extremely ordered ring-shaped 20S core structure. The core structure is comprised of 4 rings of 28 non-identical subunits； 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits.
