Histone deacetylase 8（HDAC8) is a member of the class 1 of the histone deacetylase/acuc/apha family. HDAC8 is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex. Histones play a key role in transcriptional regulation， cell cycle progression， and developmental events. Histone acetylation/deacetylation modifies chromosome structure and affects transcription factor access to DNA.
