beta type-2（PSMB2) belongs to the proteasome T1B family， which is a 20S core beta subunit. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. Proteasomes are spread throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. A crucial function of a modified proteasome， the immunoproteasome， is the processing of class I MHC peptides. PSMB2 is up-regulated in ovarian cancer cell lines.
