DUSP23 is a member of the protein-tyrosine phosphatase family. DUSP23 is a protein phosphatase which facilitates dephosphorylation of phosphorylated proteins on Tyr and Ser/Thr residues. In vitro, DUSP23 dephosphorylate p44-ERK1(MAPK3) but not p54 SAPK-beta(MAPK10). In addition, DUSP23 enhances activation of JNK and p38(MAPK14).