UBE2D1 is a member of the ubiquitin-conjugating enzyme family. Ubiquitination involves at least 3 classes of enzymes: ubiquitin-activating enzymes（E1s)， ubiquitin-conjugating enzymes（E2s) and ubiquitin-protein ligases（E3s). UBE2D1 is strongly related to a stimulator of iron transport（SFT)， and is up-regulated in hereditary hemochromatosis. In addition， UBE2D1 functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
