BPNT1 belongs to the magnesium-dependent， lithium-sensitive phosphomono-esterase superfamily. BPNT1 catalyzes the conversion of PAPS（adenosine 3’-phosphate 5’ phosphosulfate) to APS（adenosine 5’-phosphosulfate) and the conversion of PAP（3’（2’)-phosphoadenosine 5’ phosphate) to AMP（adenosine 5’-phosphate) using magnesium as a cofactor. BPNT1 is expressed everywhere but at maximum levels in brain and kidney. BPNT1 is potently inhibited by lithium， a drug used for the treatment of manic depression and bipolar affective disorder， which suggests that BPNT1 has a possible role in the etiology of mood disorders.
