17-beta-hydroxysteroid dehydrogenase 14（HSD17B14) is a member of the 17-beta-HSD family of proteins， which regulate the availability of steroids within various tissues throughout the body. 17-beta-hydroxysteroid dehydrogenases（HSD17B14) are mainly involved in metabolism of steroids at the C17 position and also of other substrates， such as fatty acids， prostaglandins， and xenobiotics. HSD17B14 exists as a homotetramer that localizes to the cytoplasm and is highly expressed in the brain， placenta， liver and kidney.
