PPIL4 belongs to an evolutionarily conserved cyclophilin-type PPIase family of proteins. PPIL4， which is ubiquitously expressed with predominant expression in kidney localizes to the nucleus and contains one PPIase cyclophilin-type domain， a lysine-rich domain， a pair of bipartite nuclear targeting sequences and one RRM（RNA recognition motif) domain. The presence of the RRM domain along with nuclear targeting sequences implies that PPIL4 may be involved in transcriptional regulation.
