PPCDC is a member of the HFCD（homo oligomeric flavin containing Cys decarboxylase) superfamily which takes a part in the biosynthesis of coenzyme A（CoA) from pantothenate（Vitamin B). The biosynthesis of CoA from pantothenate needs several steps: the phosphorylation of pantothenate， the conversion of 4’-hosphopantothenate to 4’’-phosphopantetheine， the adenylation by phosphopantetheine adenylyltransferase to form dephospho-CoA and the phosphorylation by dephospho-CoA kinase to form CoA. PPCDC is a key player in this pathway. PPCDC converts 4’’-phosphopantothenate into 4’’-phosphopantetheine.
