AASDHPPT is a member of the P-Pant transferase superfamily. AASDHPPT catalyzes the post-translational modification of target proteins by phosphopantetheine and can transfer the 4’-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors， such as the acyl carrier domain of FASN（in vitro). AASDHPPT is similar to Saccharomyces cerevisiae LYS5， which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. AASDHPPT is found in the heart， skeletal muscle， placenta， testis， brain， pancreas， liver and kidney. It’s been suggested that defects in the human AASDHPPT gene result in pipecolic acidemia.
