Purified Anti-PtdIns(4 5)P2 monoclonal antibody conjugated with Tetramethylrhodamine (TMR).Subclass: IgMSource: MouseApplications: ELISA ImmunofluorescenceConcentration: 0.5 – 1 mg/mLProduct Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PIP3.This antibody clone is also available as purified Fluorescein conjugated and in ascites fluid.
