93-O 17 S是一种用于产生脂质纳米颗粒以递送RNA肽和核苷酸的类胡萝卜素。93- 017 S LNP能够在小鼠中递送Cre重组酶mRNA。此外，LNP能够将Cre重组酶蛋白和Cas9：单向导RNA递送到细胞中用于基因组编辑。93-O 17 S LNP用于在注射到小鼠B16 F10肿瘤中时递送STING途径激动剂2 - 3-环GMP-AMP（cGAMP），其具有作为原位癌症疫苗的潜力。
产品描述
93-O17S is a lipidoid used for generating lipid nanoparticles to deliver RNA peptides and nucleotides. 93-O17S LNPs were able to deliver Cre recombinase mRNA in mice. In addition LNPs were able to deliver the Cre recombinase protein and Cas9:single-guide RNA into cells for genome editing. 93-O17S LNPs were used to deliver the STING pathway agonist 2′3′-Cyclic GMP-AMP (cGAMP) when injected into B16F10 tumors in mice which has potential as an in situ cancer vaccine.
