AA 3-DLin是一种可电离的脂质,用于产生用于RNA递送的脂质纳米颗粒(LNP)。与用其它可电离脂质配制的LNP不同,AA 3-DLin LNP在较高比例的磷脂和较低胆固醇(40:40:25:0.5 AA 3-DLin/DOPE/胆固醇/DMG-PEG)下表现最佳。含有AA 3-DLin的LNP能够将全长SARS-COV 2刺突蛋白mRNA递送至BALB/c小鼠并产生强烈的免疫应答。
产品描述
AA3-DLin is an ionizable lipid used in generating lipid nanoparticles (LNPs) for RNA delivery. Unlike LNPs formulated with other ionizable lipids AA3-DLin LNPs performed best with higher proportions of phospholipid and lower cholesterol (40:40:25:0.5 AA3-DLin/DOPE/cholesterol/DMG-PEG). AA3-DLin containing LNPs were able to deliver full-length SARS-COV2 spike protein mRNA to BALB/c mice and generate a strong immune response.