硝基油酸（OA-NO2）是在炎症（硝化应激）期间由过量的一氧化氮硝化油酸而形成的。OA-NO2是一种有效的信号分子，可以激活多种受体，包括TRPA 1阳离子通道和PPAR 3。9（10）-硝基油酸是9-硝基和10-硝基异构体的混合物，它们在体内以等量形成。P.S. Baker et al "Fatty Acid Transduction of Nitric Oxide signaling“ Journal of Biological Chemistry 2005 280 42464-42475;2. F. J. Schopfer et al“共价过氧化物酶体分解激活受体通过硝基脂肪酸的加合”Journal of Biological Chemistry 2010 285 12321-12333.
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Nitrooleic acid (OA-NO2) is formed by nitration of oleic acid from excessive nitric oxide during inflammation (nitrative stress). OA-NO2 is a potent signaling molecule which can activate numerous receptors including TRPA1 cation channels and PPARγ. 9(10)-Nitrooleic acid is a mixture of the 9-nitro and 10-nitro isomers which are formed in equal amounts in vivo.References1. P.S. Baker et al “Fatty Acid Transduction of Nitric Oxide signaling†Journal of Biological Chemistry 2005 280 42464-42475;2. F.J. Schopfer et al “Covalent Peroxisome Proliferator-Activated Receptor Adduction By Nitro-Fatty Acid†Journal of Biological Chemistry 2010 285 12321-12333.
