1-硬脂酰-2-花生四烯酸-sn-甘油是一种甘油二酯（DAG），其sn-1和sn-2位分别含有花生四烯酸和硬脂酸。1-硬脂酰-2-花生四烯酸-sn-甘油是一种甘油二酯，是PKC β ± PKC β μ和PKC β ′的有效激活剂，也与Ras激活剂RasGRP竞争性结合。1 2-二酰基甘油通过磷脂酶C水解磷脂酰肌醇4 5-二磷酸在细胞中形成。DAG激活蛋白激酶C（PKC），其是信号转导细胞调节和肿瘤促进的关键调节剂。 加农B.R. &贝尔 （1985）“Exogenous sn-1 2-diacylglycerols Containing Saturated Fatty Acids Functions as Bioregulators of Protein Kinase C in Human Plastomy”J.Biol.Chem.260 1358- 1361. 卢米斯C.R. Hannun Y.A. &贝尔 （1986）“Specificity and Mechanism of Protein Kinase C Activation by sn-1 2-diacylglycerols”Proc.Natl. Acad. Sci.美国83 1184-1188.
产品描述
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) with polyunsaturated fatty acid arachidonic acid and stearic acid in the sn-1 and sn-2 positions respectively. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol is a potent activator of PKCα PKCε and PKCδ and also competitively binds to the Ras activator RasGRP. 1 2-Diacylglycerols are formed in cells through the hydrolysis of phosphatidylinositol 4 5-bisphosphate by Phospholipase C. DAGs activate Protein Kinase C (PKC) which is a key regulator of signal transduction cellular regulation and tumor promotion.References1) Lapetina E.G. Reep B. Ganong B.R. & Bell R.M. (1985) "Exogenous sn-1 2-diacylglycerols Containing Saturated Fatty Acids Functions as Bioregulators of Protein Kinase C in Human Platelets" J. Biol. Chem. 260 1358-1361.2) Ganong B.R. Loomis C.R. Hannun Y.A. & Bell R.M. (1986) "Specificity and Mechanism of Protein Kinase C Activation by sn-1 2-diacylglycerols" Proc. Natl. Acad. Sci. USA 83 1184-1188.
