NOG是α-酮戊二酸的类似物,并且已发现是涉及α-酮戊二酸的反应如黄嘌呤羟化酶和α-酮戊二酸双加氧酶的抑制剂。M. M. Li等人(2007年)。“来自构巢曲霉的Fe II和α-酮戊二酸依赖性黄嘌呤羟化酶的纯化和表征。“生物化学46(18):5293-304.2) P. K. Grzyska等人(2005年)。“CoII、NiII和N-草酰甘氨酸抑制FeII/α-酮戊二酸双加氧酶TauD的动力学和光谱研究。“Biochem Biophys Res Commun 338(1):191-7。
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NOG is an analogue of alpha ketoglutarate and has been found to be an inhibitor of reactions involving alpha ketoglutarate such as xanthine hydroxylase and alpha ketoglutarate dioxygenase.References1) Montero-Moran G. M. M. Li et al. (2007). "Purification and characterization of the FeII- and alpha-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans." Biochemistry 46(18): 5293-304.2) Kalliri E. P. K. Grzyska et al. (2005). "Kinetic and spectroscopic investigation of CoII NiII and N-oxalylglycine inhibition of the FeII/alpha-ketoglutarate dioxygenase TauD." Biochem Biophys Res Commun 338(1): 191-7.