PS48通过仅与PIF结合口袋而不是ATP结合位点结合来激活磷酸肌醇依赖性蛋白激酶1（PDK 1）。Stroba等人，“5-Diphenyleneorbenzo-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK 1：Structure-Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds”，J. Med. Chem 2009 52（15）4683-46932）L.D. Spate et al.“PS48可以取代猪胚胎培养基中的牛血清白蛋白，通过磷酸化AKT改善体外胚胎发育”《分子生殖发展》2015 DOI：10.1002/mrd.22474。
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PS48 activates phosphoinositide-dependent protein kinase 1 (PDK1) by binding exclusively to PIF-binding pocket rather than the ATP binding site.References1) A. Stroba et al. “3 5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure-Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds†J. Med. Chem 2009 52 (15) 4683-46932) L.D. Spate et al. “PS48 can replace bovine serum albumin in pig embryo culture medium and improve in vitro embryo development by phosphorylating AKT†Molecular Reproduction & Development 2015 DOI: 10.1002/mrd.22474.
