AS 1949490是一种有效的选择性SHIP 2抑制剂，对人的IC 50为0.62 μ M，对SHIP 1影响较小或对其他类型的细胞内磷酸酶（如PTEN synaptojanin和myotubularin）无影响。该化合物还能激活肝脏中的细胞内胰岛素信号通路，并显示出促胰岛素生成调节和抗糖尿病作用。苏瓦河Yamanoto等人，“Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase SHIP 2”British Journal of Pharmacology 2009 158 879-88.
产品描述
AS1949490 is a potent selective SHIP2 inhibitor with IC50 of 0.62 uM for human which shows less effect on SHIP1 or no effects on some other types of intracellular phosphatases (such as PTEN synaptojanin and myotubularin). This compound also activates intracellular insulin signaling pathways in the liver and displays gluconeogensis regulation and antidiabetic effects.References Powered by Bioz See more details on BiozA. Suwa T. Yamanoto et al. "Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase SHIP2" British Journal of Pharmacology 2009 158 879-88.
