5-(2-二氟-苯并[1 3]间二氧杂环戊烯-5-基亚甲基)-噻唑烷-2-4-二酮(AS 604850)是PI 3-Ketamine 3的抑制剂,IC 50 = 250 nM。AS 604850对β 3-亚型具有选择性(IC 50:PI 3-Keto 2 = 4.5 μ M PI 3-Keto 2 PI 3-Keto 2 20 μ M),在1 μ M浓度下对多种蛋白激酶无明显活性。参考资料由Bioz提供技术支持更多详情请参阅Bioz 1)M。Camps等人,“Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis”Nature Medicine 2005 11 936-943.
产品描述
5-(2 2-Difluoro-benzo[1 3]dioxol-5-ylmethylene)-thiazolidine-2 4-dione (AS604850) is an inhibitor of PI 3-Kγ with an IC50 = 250 nM. AS604850 is selective for the γ-isoform (IC50: PI 3-Kα = 4.5 μM PI 3-Kβ PI 3-Kδ > 20 μM) and shows no notable activity against a wide array of protein kinases at 1 μM.References Powered by Bioz See more details on Bioz1) M. Camps et al. "Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis" Nature Medicine 2005 11 936-943.