NVP-231是一种有效的特异性和可逆的神经酰胺激酶（CerK）抑制剂（体外IC 50 = 12 nM），可竞争性抑制神经酰胺的结合。CerK是控制神经酰胺水平的关键酶。 等人，Targeting Ceramide Metabolism with a Potent and Specific Ceramide Kinase Inhibitor; Molecular Pharmacology 2008 74（4）：925-932
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NVP-231 is a potent specific and reversible Ceramide kinase (CerK) inhibitor (IC50= 12 nM in vitro) which competitively inhibits binding of ceramide. CerK is a key enzyme for controlling ceramide levels.ReferencesGraf C. et al. Targeting Ceramide Metabolism with a Potent and Specific Ceramide Kinase Inhibitor; Molecular Pharmacology 2008 74(4): 925-932
