Trismethoxyresveratrol (3 5 4'-Trimethoxystilbene) induces microtubule disassembly and tubulin depolimerization. it is also a powerful antiangiogenetic agent and inhibits endothelial cell proliferation morphogenesis sprouting and collagen gel invasion.ReferencesM. Belleri et al. Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3 5 4'-trimethoxystilbene. Mol. Pharmacol. 2005 67 1451