CAS号：138579-66- 5分子量：2198.1盐形式：TFAP纯度：90%序列（3个字母）：Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH 2序列（1个字母）：GWTLNSAGYLLGPQQFFGLM-NH 2储存温度：-20 °C或以下Galantide是甘丙肽和P物质片段组成的嵌合肽，作为甘丙肽受体的可逆拮抗剂。该肽以剂量依赖性方式拮抗甘丙肽介导的对葡萄糖诱导的小鼠胰岛胰岛素分泌的抑制作用（IC 50 = 1.0 nM）。它拮抗甘丙肽诱导的K+电导增加（IC 50 = 4 nM）。参考文献1）Lindskog S et al. The novel high-affinity antagonist galantide blocks the galanin-mediated inhibition of glucose-induced insulin secretion.欧洲药理学杂志1992;210（2）：183-188.2）Mulvaney JM等人Galantide区分了泥小狗副交感神经元中甘丙肽受体的推定亚型。欧洲药理学杂志1995;287（1）：97-100.
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CAS Number: 138579-66-5Molecular Weight: 2198.1Salt Form: TFAPurity: >90%Sequence (3-letter): Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2Sequence (1-letter): GWTLNSAGYLLGPQQFFGLM-NH2Storage: -20 °C or belowGalantide is a chimeric peptide consisting of fragments of galanin and Substance P which acts as a reversible galanin receptor antagonist. The peptide antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets in a dose-dependant manner (IC50 = 1.0 nM). It antagonizes the galanin-induced increase in K+ conductance IC50 = 4 nM).References1) Lindskog S et al. The novel high-affinity antagonist galantide blocks the galanin-mediated inhibition of glucose-induced insulin secretion. Eur J Pharmacol. 1992;210(2):183-188.2) Mulvaney JM et al. Galantide distinguishes putative subtypes of galanin receptors in mudpuppy parasympathetic neurons. Eur J Pharmacol. 1995;287(1):97-100.
