Avelumab (Bavencio®) is a fully human anti-PD-L1 IgG1 lambda monoclonal antibody that has a molecular weight of approximately 147 kDa. Avelumab binds PD-L1 and blocks the interaction between PD-L1 and its receptors PD-1 and B7-1. By inhibiting PD-L1 interactions, avelumab is thought to enable the activation of T-cells and the adaptive immune system. By retaining anative Fc-region, avelumab is thought to engage the innate immune system and may induce antibody-dependent cell-mediated cytotoxicity. Importantly, avelumab has not shown antibody-dependent cellmediated cytotoxicity against immune cell subsets in humans. BioSim™ Avelumab ELISA kit has been developed for specific quantification of Avelumab concentration in human serum or plasma with high sensitivity and reproducibility.
产品特点
Easy, convenient, sensitive and time-saving method to measure the level of Avelumab in human serum and plasma.
Detection Range: 100 - 3000 ng/ml
Sensitivity: 30 ng/ml
Assay Precision: Intra-Assay: CV < 15%; Inter-Assay: CV < 15% (CV (%) = SD/mean X 100)
Cross Reactivity: No significant cross-reactivity or interference with other proteins present in native human serum or other therapeutic immunoglobulins.
Recovery rate: 85 – 115% with normal human serum samples with known concentrations
