- 中文名称
ErbB2, phosphorylated (Tyr1221/1222) (c-erbB2, HER2), BioAssay ELISA Kit (Human)
- 英文名字
- ErbB2, phosphorylated (Tyr1221/1222) (c-erbB2, HER2), BioAssay ELISA Kit (Human)
- 供应商
- USBiological
- 产品货号
- E3451-35P
- 产品报价
- ￥1/1Kit
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！
- 产品描述
- The ErbB2 (HER2) proto-oncogene encodes a transmembrane receptor-like glycoprotein of 185kD with intrinsic tyrosine kinase activity (1). ErbB2 does not have any known ligand. However, the kinase activity of ErbB2 can be activated without ligand if it is overexpressed and by heteromeric association with other members of the ErbB family (2). Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers (3). Binding of the c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas. Direction of ErbB2 to the c-Cbl-regulated proteolytic pathway may have therapeutic potential. Tyr877 of ErbB2 is homologous to Tyr416 of pp60c-Src, located in the kinase domain. Phosphorylation of this site may be involved in regulation of ErbB2 biological activity. Tyr1248 and Tyr1221/1222 are the major autophosphorylation sites in ErbB2. Phosphorylation of these sites couples ErbB2 to the Ras-Raf-MAP kinase signal transduction pathway (1,5).1 Kit (96 assays)12 8-well modules –Each module is designed to break apart for 8 tests.Kit IncludesVolumeSolution ColorHER2/ErbB2 mouse mAb coated microwells96 testsPhospho-HER2/ErbB2 (Tyr1221/1222) Detection Ab11 mlGreenAnti-rabbit IgG HRP-Linked Ab11 mlRedTMB Substrate11 mlColorlessSTOP Solution11 mlColorless20X Wash Buffer25 mlColorlessSample Diluent25 m/BlueSealing Tape2 sheetsCell Lysis Buffer (10X) 15 mlKit should be stored at 4°C with the exception of Cell Lysis Buffer (10X), which is stored at -20°C (packaged separately).
- 产品特点
- 针对ErbB2, phosphorylated (Tyr1221/1222) (c-erbB2, HER2), BioAssay ELISA Kit (Human)该产品的特点优势，欢迎查阅官网提供的产品说明书。
- 保存建议
- 建议收到ErbB2, phosphorylated (Tyr1221/1222) (c-erbB2, HER2), BioAssay ELISA Kit (Human)产品后将其置于-20°C保存。
- 其他
- Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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