FGF4 holds s comprehensive mitogenic and cell survival activities and takes part in a range of biological processes including embryonic development，cell growth，morphogenesis，tissue repair，tumor growth and invasion. FGF4 possess oncogenic transforming activity. FGF4 and FGF3，oncogenic growth factors are localized on chromosome 11. Co-amplification of both factors was found in several kinds of human tumors. FGF4 functions in bone morphogenesis and limb development through the sonic hedgehog （SHH） signaling pathway.
