AIMP1 (EMPA2 or p43) is a cytokine that is specifically induced by apoptosis,and it is involved in the control of angiogenesis,inflammation,and wound healing. The release of the AIMP1 cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. Furthermore,AIMP1 is involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells.