Alprenolol is an antagonist for ß1 and ß2 adrenergic receptors. Alprenolol agarose affinity chromatography was first introduced by Lefkowitz R. J. in 1979 for the purification of erythrocyte ß-adrenergic receptor based on ligand-receptor interactions. It is now routinely used for the purification of functionally active ß1 and ß2-adrenergic receptor. CellMosaic’s SepSphere™ Alprenolol Agarose is composed of Agarose 4B Beads linked to alprenolol via a thiol ether linkage.