S-methyl DM1 is the primary cellular or liver metabolite of ADC or other conjugates prepared with DM1. DM1 (mertansine) is a thiol-containing derivative of maytansine. It binds to tubulin and inhibits the assembly of microtubules. DM1 is used to prepare antibody-drug conjugates, such as trastuzumab emtansine (abbreviated as T-DM1). DM1 is not very stable in aqueous solution and can be oxidized or dimerized.nnCellMosaic’s S-methyl DM1 is a high purity product that can serve as a standard for HPLC and LC-MS/MS analysis. The product is formulated in DMSO solution, quantified by UV/HPLC using DM1 as standard/calibrator at 252 nm, and ready to use after dilution. Although S-methyl DM1 inhibits polymerization weaker than DM1, it can also be used as a stable control for ADC studies instead of DM1.nnThe product is sold as 1 vial of 1 mg (133 uL x 10 mM). If you would like to buy multiple vials, please check our Bulk Pricing:Buy in bulk and save.
