- 中文名称
MAL-dPEG ®甘草酸-100 mg
- 英文名字
- MAL-dPEG®₁₂-acid-100 mg
- 供应商
- Click Chemistry Tools
- 产品货号
- CCT-QBD-10285-100
- 产品报价
- ¥询价/100mg

- 产品说明书
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- 购买方式
- 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系。本公司所有产品仅供科研使用,不用于临床诊断。
- 产品新闻

- 背景资料
- MAL-dPEG®12-酸(产品编号QBD-10285)是一种交联剂,通过离散长度的单分子量聚乙二醇(PEG)链将巯基连接到游离胺上。马来酰亚胺基丙基部分通过迈克尔加成反应与巯基反应。分子的丙酸末端使用EDC或另一种碳二亚胺直接与游离胺反应以形成酰胺键。或者,用N-羟基琥珀酰亚胺(NHS)、2,3,5,6-四氟苯酚(TFP)或一些其它酰化剂活化丙酸基团允许在温和的受控条件下形成酰胺键。
- 产品描述
- MAL-dPEG®12-acid, product number QBD-10285, is a crosslinker that joins sulfhydryl groups to free amines through a single molecular weight polyethylene glycol (PEG) chain of discrete length. The maleimidopropyl moiety reacts with sulfhydryl groups via a Michael addition reaction. The propionic acid terminus of the molecule reacts directly with free amines using EDC or another carbodiimide to form amide bonds. Alternatively, activation of the propionic acid group with N-hydroxysuccinimide (NHS), 2,3,5,6-tetrafluorophenol (TFP), or some other acylating agent permits amide bond formation under mild, controlled conditions.nChemical couplings between free amines and free thiols are among the most popular, most useful crosslinking reactions in bioconjugate chemistry. These syntheses require heterobifunctional reagents that bridge the two groups. While traditional crosslinkers are hydrophobic molecules, Vector Laboratories' crosslinking products are water-soluble, amphiphilic, single molecular weight PEG compounds with discrete chain lengths, hence the dPEG® tradename under which we sell them. Almost inevitably, the conjugation of conventional hydrophobic crosslinking reagents to biomolecules triggers problems such as aggregation and precipitation of the conjugates. Conversely, these problems do not occur with our water-soluble, non-immunogenic dPEG® crosslinkers.nThe reaction of the maleimide end of MAL-dPEG®12-acid with a sulfhydryl proceeds optimally at pH 6.5 – 7.5. Use the lowest reasonable pH within this range. Above pH 7.5, free amines compete with free thiols at the maleimide reaction site, which can cause confusing results. Moreover, at higher pH values, the maleimide ring may open to form unreactive maleamic acid.nAfter the maleimide end of the molecule reacts with a sulfhydryl, the terminal propionic acid group may be left unreacted for charge modification or the conjugate or activated with an acylating agent such as NHS or TFP. The active ester then reacts with free amines to complete the crosslink.
- 产品形式
- 白色至类白色固体
- 保存建议
- 其他
- Click Chemistry Tools(CCT)公司位于美国亚利桑那州斯科茨代尔(Scottsdale,AZ)。自公司成立以来,一致致力于不断开发和扩展一系列连接产品。他们利用特别新的研究成果研发生产出新颖的交联和标记试剂。产品被广泛用于药物研发、癌症治疗以及各类诊断技术等。此外,CCT还可以提供个性化的定制产品,已满足不同用户的需求。目前CCT的产品线主要包括:Azides(Biotin-Azides)试剂、Bis-sulfone交联试剂、DBCO试剂、TCO试剂、Terminal Alkyne试剂、Tetrazine试剂、标记试剂盒以及分选用底物等。nFluoroprobes公司位于美国亚利桑那州斯科茨代尔(Scottsdale, AZ),自成立以来,一直致力于不断开发一系列的连接(linker)产品。利用特别新的研究成果研发生产出各类新颖的交联和标记试剂。其产品被广泛用于药物研发与筛选、疾病治疗方法和诊断技术等领域。此外,Fluoroprobes还可以根据客户的个性化需求提供各类定制连接产品。代表产品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些标记试剂盒等。nQuanta Biodesign公司位于美国中部的俄亥俄州,成立于1997年。也是专注于生产研发各类标记产品的品牌之一。其研发的产品与dPEG技术相结合,生产出他们独有的专利产品dPEG Building Blocks and Linkers,被广泛用于细胞治疗和分子诊断等研究领域。另外,还可为广大科研工作者提供多种化学修饰试剂以及传统Liner等。n目前上述三个品牌都已被被Vectorlabs收购并整合到Vectorlabs产品中

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该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
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