- 中文名称
Amino-dPEG ®氨基-叔丁基酯-1000 mg
- 英文名字
- Amino-dPEG®₁₂-t-butyl ester-1000 mg
- 供应商
- Click Chemistry Tools
- 产品货号
- CCT-QBD-10281-1000
- 产品报价
- ¥询价/1000mg

- 产品说明书
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- 购买方式
- 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系。本公司所有产品仅供科研使用,不用于临床诊断。
- 产品新闻

- 背景资料
- Amino-dPEG®12-叔丁基酯(产品编号QBD-10281)是一种具有羰基和胺反应性的单分子量聚乙二醇(PEG)产品,具有离散链长。该化合物由位于离散PEG(dPEG®)间隔基的相对端上的伯胺和丙酸叔丁酯组成。分子的胺端容易与醛和酮反应形成可还原的席夫碱,并与羧酸及其活性酯(NHS,TFP)反应形成酰胺键。叔丁基酯基团保护产物的丙酸末端。该酯可用三氟乙酸(TFA)裂解,留下丙酸部分自由地与胺反应,通过用酰化试剂活化或通过使用碳二亚胺直接偶联至胺。
- 产品描述
- Amino-dPEG®12–t-butyl ester, product number QBD-10281, is a carbonyl- and amine-reactive, single molecular weight polyethylene glycol (PEG) product with a discrete chain length. The compound consists of a primary amine and a propionic acid tert-butyl ester on opposite ends of a discrete PEG (dPEG®) spacer. The amine end of the molecule reacts readily with aldehydes and ketones to form reducible Schiff bases and with carboxylic acids and their active esters (NHS, TFP) to form amide bonds. A tert-butyl ester group protects the propionic acid end of the product. The ester is cleavable with trifluoroacetic acid (TFA), leaving the propionic acid moiety free to react with amines either by activation with an acylation reagent or by direct coupling to an amine using a carbodiimide.nThis product can be used in peptide synthesis, protein modification, other forms of supramolecular construction, and as a novel, monoprotected heterobifunctional crosslinker. The dPEG® spacer is not a dispersed polymer with a range of chain lengths and molecular weights but a very high purity, single molecular weight PEG chain with a discrete chain length. One of the advantages of dPEG® compounds is that analyses of conjugates made with dPEG® linkers are simplified since only one chain length and molecular weight of PEG is present. Moreover, our amphiphilic dPEG® products impart water solubility to conjugates made with them, often improving the performance of the conjugate compared to the parent molecule.nPublished applications for Amino-dPEG®12–t-butyl ester include the following:nDevelopment of anti-fouling surfaces;nCreation of targeted NIR and non-peptidic SPECT imaging products to act as guides for surgical removal of cancerous growths; and,nCreation of highly specific crosslinkers for the development of antibody-drug conjugates (ADCs).
- 产品形式
- 无色至浅琥珀色油状物;储存条件下为固体
- 保存建议
- 其他
- Click Chemistry Tools(CCT)公司位于美国亚利桑那州斯科茨代尔(Scottsdale,AZ)。自公司成立以来,一致致力于不断开发和扩展一系列连接产品。他们利用特别新的研究成果研发生产出新颖的交联和标记试剂。产品被广泛用于药物研发、癌症治疗以及各类诊断技术等。此外,CCT还可以提供个性化的定制产品,已满足不同用户的需求。目前CCT的产品线主要包括:Azides(Biotin-Azides)试剂、Bis-sulfone交联试剂、DBCO试剂、TCO试剂、Terminal Alkyne试剂、Tetrazine试剂、标记试剂盒以及分选用底物等。nFluoroprobes公司位于美国亚利桑那州斯科茨代尔(Scottsdale, AZ),自成立以来,一直致力于不断开发一系列的连接(linker)产品。利用特别新的研究成果研发生产出各类新颖的交联和标记试剂。其产品被广泛用于药物研发与筛选、疾病治疗方法和诊断技术等领域。此外,Fluoroprobes还可以根据客户的个性化需求提供各类定制连接产品。代表产品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些标记试剂盒等。nQuanta Biodesign公司位于美国中部的俄亥俄州,成立于1997年。也是专注于生产研发各类标记产品的品牌之一。其研发的产品与dPEG技术相结合,生产出他们独有的专利产品dPEG Building Blocks and Linkers,被广泛用于细胞治疗和分子诊断等研究领域。另外,还可为广大科研工作者提供多种化学修饰试剂以及传统Liner等。n目前上述三个品牌都已被被Vectorlabs收购并整合到Vectorlabs产品中

- 注意
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该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
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