ADCY5 encodes a member (adenylate cyclase 5) of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for ADCY5.
应用类型
WB,IHC-F,IHC-P,ICC/IF,ELISA
免疫原
The antiserum was produced against synthesized peptide derived from human ADCY5/6. AA range:931-980
