May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit .
应用类型
WB,IHC-P,ELISA
免疫原
The antiserum was produced against synthesized peptide derived from human IRS-1 around the phosphorylation site of Ser639. AA range:605-654
